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Although ABM domains were initially discovered (and named) for their roles in antibiotic biosynthesis 43 , they have since been shown to play more diverse roles in cellular metabolism with the discovery of their involvement in the enzymatic degradation of heme 52,53

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Besides, TQ prevented LPS-activated neuroinflammation in BV2 microglia by activating liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1) [50]

Thus, our data strongly suggest that the local injection of IKE + DHAA induce ferroptosis in vivo in the tumor area and could have highly beneficial effects for the eradication of highly aggressive tumors